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dc.contributor.authorAvendaño, Maria Eugenia-
dc.contributor.authorPoletto, Adriana-
dc.contributor.authorBonanno, Marina Soledad-
dc.contributor.authorDavison, Mario Ricardo-
dc.contributor.authorZeni, Susana Noemi-
dc.date.accessioned2023-05-03T16:34:08Z-
dc.date.available2023-05-03T16:34:08Z-
dc.date.issued2020-11-
dc.identifier.urihttp://rid.unrn.edu.ar/handle/20.500.12049/10100-
dc.language.isoenes_ES
dc.relation.urihttps://www.medicinabuenosaires.com/es_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/-
dc.titleAssessment of jawbone microarchitecture in bisphosphonate- treated sheep by cone-beam computed tomographyes_ES
dc.typeObjeto de conferenciaes_ES
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)-
dc.description.filiationAvendaño, Maria Eugenia. Universidad Nacional de Cuyoes_ES
dc.description.filiationPoletto, Adriana. Facultad de Odontología.Universidad Nacional de Cuyoes_ES
dc.description.filiationBonanno, Marina Soledad. INIGEM.UBA.CONICETes_ES
dc.description.filiationDavison, Mario Ricardo. Universidad Nacional de Rio Negro. Río Negro; Argentina.es_ES
dc.description.filiationZeni, Susana Noemi. UBA/CONICET.es_ES
dc.subject.keywordTomografíaes_ES
dc.subject.keywordHuesoes_ES
dc.subject.keywordPTHes_ES
dc.subject.keywordBifosfonatoses_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dc.subject.materiaCiencias Médicas y de la Saludes_ES
dc.origin.lugarDesarrolloUniversidad Nacional de Río Negroes_ES
dc.description.resumenThe cone-beam computed tomography (CBCT) is a non-invasive 3D reconstruction technique that enables to assess jawbone micro-architecture. It is used to illustrate results through 3D images. In the present report, the combination of CBCT with other techniques was used to evaluate changes in composition and micro-architectural structure quantity of the ewe jawbone after oestrogen withdrawal (OVX) and/or chronic treatment with high doses of zoledronic acid (zol). Three groups of adult Corriedale ewes, 35 to 40 kg body weight were used: OVX: OVX ewes receiving saline solution; ZOL: OVX ewes treated with Zol (4 mg/month) for 28 months for high cumulative dose of ZOL in bones and SHAM: SHAM ewes receiving saline solution (control). At the end of the study, hemi-mandibles were extracted: Bone mineral density (BMD) and content (BMC) of the mandibles were evaluated ex vivo by DXA (Lunar DPX); CBCT was performed using Planmeca Promax 3D Classic. Results of CBCT: OVX as compared to SHAM ewes significantly decreased BMC and BMD (p<0.001); BV/ TV (%), Tb. Th, connectivity and anisotropy (p<0.0075; p<0.0075, p<0.001 and p<0.02, respectively) while Tb. Sp (p<􏰏0.0002) was significantly increased. Zol treatment did not show statistical differences when compared to SHAM group. Zol showed values of anisotropy significantly higher than OVX group (p<0.018) and Tb.Sp significantly lower than OVX groups (p<0.043). BV/ TV (%), Tb. Th and connectivity as compared to OVX group showed a clear tendency to be higher and almost reached significance (p=0.055; p=0.061 and p=0.054, respectively. Maxillary BMC and BMD were lowest in OVX ewes (p<0.05) and were significantly higher in ZOL than in SHAM ewes (p<0.05). Conclusion: The CBCT technique was useful to evaluate the deterioration of the bone quality by estrogen withdrawal and the recovery by ZOL treatment.es_ES
dc.relation.journalTitleREUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2020 / LXV REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC) / LXVIII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA (SAI) / REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE FISIOLOGÍA (SAFIS)es_ES
dc.type.subtypeResumenes_ES
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