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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | Bonanno, Marina Soledad | - |
| dc.contributor.author | Zeni Coronel, Estefanía Magalí | - |
| dc.contributor.author | Seijo, Mariana | - |
| dc.contributor.author | Bidevich, Nicolas Lautaro | - |
| dc.contributor.author | Avendaño, Maria Eugenia | - |
| dc.contributor.author | Preliasco, Mariana | - |
| dc.contributor.author | Davison, Mario Ricardo | - |
| dc.contributor.author | Zeni, Susana Noemi | - |
| dc.date.accessioned | 2023-11-22T11:27:47Z | - |
| dc.date.available | 2023-11-22T11:27:47Z | - |
| dc.date.issued | 2022-11-16 | - |
| dc.identifier.other | https://drive.google.com/file/d/1XG4tcc9aXzJeCw1uPT5z__Eyly9ShE_q/view | es_ES |
| dc.identifier.uri | http://rid.unrn.edu.ar/handle/20.500.12049/11016 | - |
| dc.language.iso | es | es_ES |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | - |
| dc.title | Resorbed alveolar bone recovery by treatment with pth 1-34 at low doses in experimental periodontitis | es_ES |
| dc.type | Objeto de conferencia | es_ES |
| dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | - |
| dc.description.filiation | Bonanno, Marina Soledad. Laboratory of Metabolic Osteopathies. Institute of Immuno- logy, Genetics and Metabolism (INIGEM), CONICET, School of Pharmacy and Biochemistry (FFyB), Buenos Aires Univer- sity (UBA). Buenos Aires; Argentina. | es_ES |
| dc.description.filiation | Zeni Coronel, Estefanía Magalí. Laboratory of Metabolic Osteopathies. Institute of Immuno- logy, Genetics and Metabolism (INIGEM), CONICET, School of Pharmacy and Biochemistry (FFyB), Buenos Aires Univer- sity (UBA). Buenos Aires; Argentina. | es_ES |
| dc.description.filiation | Seijo, Mariana. Laboratory of Metabolic Osteopathies. Institute of Immuno- logy, Genetics and Metabolism (INIGEM), CONICET, School of Pharmacy and Biochemistry (FFyB), Buenos Aires Univer- sity (UBA). Buenos Aires; Argentina. | es_ES |
| dc.description.filiation | Bidevich, Nicolas Lautaro. Dental career, FNRN. Argentina. | es_ES |
| dc.description.filiation | Avendaño, Maria Eugenia. Universidad Nacional de Río Negro. Río Negro; Argentina. | es_ES |
| dc.description.filiation | Preliasco, Mariana. Universidad Nacional de Río Negro. Río Negro; Argentina. | es_ES |
| dc.description.filiation | Davison, Mario Ricardo. Universidad Nacional de Río Negro. Río Negro; Argentina. | es_ES |
| dc.description.filiation | Zeni, Susana Noemi. Universidad Nacional de Río Negro. Río Negro; Argentina. | es_ES |
| dc.subject.keyword | Osteología | es_ES |
| dc.subject.keyword | Metabolismo óseo | es_ES |
| dc.subject.keyword | Farmacología | es_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
| dc.subject.materia | Ciencias Médicas y de la Salud | es_ES |
| dc.origin.lugarDesarrollo | Universidad Nacional de Río Negro | es_ES |
| dc.origin.lugarDesarrollo | INIGEM | es_ES |
| dc.origin.lugarDesarrollo | FACULTAD DE ODONTOLOGÍA. UNIVERSIDAD NACIONAL DE CUYO | es_ES |
| dc.description.resumen | We compared two low doses of PTH for the recovery of alveolar bone loss by experimental periodontitis. Periodontitis was induced in 18 female Wistar rats (221±15g); 96 hours later, rats were divided and treated by injection into the gingival sulcus: G1: saline solution (SS), G2 and G3 with 0.2 or 0,4 μg PTH 1-34/Kg/3 times a week. A control group (C) (n=5) without ligature was injected with SS. Af- ter 21 days, serum was extracted to determine CrossLapp (CTX), osteocalcin (OCN) and PTH by ELISA. Animals were euthanized and hemimandibles (HM) and tibias (T) were extracted for histomorphometry (percent bone volume: BV/TB% and periodontal space height: PSA). Results (C, G1, G2 y G3 respectively. Mean±SD, different letters indicate p<0.05): BV/TV% T 45.7±5.4; 41.3±5.4; 46.6±2.7; 44.1±3.0. BV/TV% HM 486±5.6b; 36.4±4.4a; 43.8±1.7ab; 48.7±6.5b. AEP (μm) 168.3±24.2a; 634.2±125.3c; 686.6±71.7c; 354.1±43.6b. CTX (pg/mL) 47.0±15.3a; 71.7±15.7b; 45.4±10.7a; 42.8±9.8a. OCN (ng/mL) 2.4±0.0a; 2.7±0.0c; 2.5±0.1a; 2.6±0.0b. PTH (pg/mL) 17.7±0.5; 16.7±1.2; 13.5±3.9; 13.7±3.5.Tibia BV/TV% did not evidence systemic effects by PTH treatment. Periodontitis increased bone remodeling while PTH treatment decreased bone resorption. G3 showed an increase in OCN levels without changes in CTX levels along with a significant improvement in hemimandible BV/TV% and a high recovery of AEP when compared to C group. Conversely, G1 cannot reach the values of C. Levels of PTH did not change with periodontitis induction or pharmacological treatment. Conclusions: intermittent administration of PTH in the high low dose tested decreased the progression of periodontal disease without inducing systemic effects suggesting an additional successful treat- ment for periodontitis. Grants of CONICET and UNRN | es_ES |
| dc.relation.journalTitle | REUNIÓN CONJUNTA SAIC SAI&FAIC SAFIS 2022 | es_ES |
| dc.type.subtype | Resumen | es_ES |
| Aparece en las colecciones: | Objetos de conferencia | |
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|---|---|---|---|---|
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