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dc.contributor.authorPellegrini, Gretel Gisela-
dc.contributor.authorBonanno, Marina Soledad-
dc.contributor.authorZeni Coronel, Estefanía Magalí-
dc.contributor.authorOrsuza, R-
dc.contributor.authorAvendaño, Maria Eugenia-
dc.contributor.authorZeni, Susana Noemi-
dc.date.accessioned2023-11-22T11:38:58Z-
dc.date.available2023-11-22T11:38:58Z-
dc.date.issued2022-11-16-
dc.identifier.urihttp://rid.unrn.edu.ar/handle/20.500.12049/11017-
dc.language.isoeses_ES
dc.relation.urihttps://drive.google.com/file/d/1XG4tcc9aXzJeCw1uPT5z__Eyly9ShE_q/viewes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/-
dc.titleEffects of the addition of teriparatide to a bovine bone grafting material on the repair of critical-sized bone defects in rats. Preliminaryes_ES
dc.typeObjeto de conferenciaes_ES
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)-
dc.description.filiationPellegrini, Gretel Gisela. Universidad Nacional de Río Negro. Río Negro; Argentina.es_ES
dc.description.filiationBonanno, Marina Soledad. Universidad Nacional de Río Negro. Río Negro; Argentina.es_ES
dc.description.filiationZeni Coronel, Estefanía Magalí. Universidad Nacional de Río Negro. Río Negro; Argentina.es_ES
dc.description.filiationOrsuza, R. Universidad Nacional de Río Negro. Río Negro; Argentina.es_ES
dc.description.filiationAvendaño, Maria Eugenia. Universidad Nacional de Río Negro. Río Negro; Argentina.es_ES
dc.description.filiationZeni, Susana Noemi. Universidad Nacional de Río Negro. Río Negro; Argentina.es_ES
dc.subject.keywordOsteologíaes_ES
dc.subject.keywordMetabolismo óseoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dc.subject.materiaCiencias Médicas y de la Saludes_ES
dc.origin.lugarDesarrolloUniversidad Nacional de Río Negroes_ES
dc.description.resumenWe previously determined the osteoconductive effect of a bovine bone graft manufactured in Argentina [Synergy Bone Matrix, Odontit Implant Systems, Argentina (SBM)], on the bone healing process in an experimental model in rats. Several studies have shown that intermittently administered PTH has an anabolic effect on cancellous and cortical bone. On these bases, we hypothesized that the addition of the synthetic PTH analog, Teriparatide (TPT), to SBM could accelerate bone regeneration. The aim of the present experimental study was to evaluate if the addition of TPT to SBM presents any additional beneficial effect versus the use of SBM alone. Thirty adult male Wistar rats of 333±39.22 (n=6/group) and a critical-size bone defect (CSD) was created in the medial aspect of both tibiae. All CSDs received one of the following treatments for 30 days: G1: control without treatment; G2: SBM (Lot No: E11121216); G3: SBM mixed with 20 μg of T (Osteofortil, BioSidus, Argentina); G4: injection of 0.125 μg/day of TPT and G5: SBM mixed with 20 μg of TPT and SC injection of 0.125 μg/day of the same drug. The animals were sacrificed 45 days after the beginning of the experiment. We analyzed serum PTH, P1NP and CTX (ELISA). At the end of the study, the tibiae were evaluated with X-ray microtomography (μCT). Serum PTH levels (pg/mL) at the end of the study were 4.6±1.2a; 11.3±2.3b; 16.4±0.7c; 17.9±0.8c and 19.1±0.5c, respectively, P1NP levels (pg/L) at the end of the study were 2.24±0.24a; 2.63±0.16c; 2.54±0.37c; 2.43±0.41b; 2.48±0.45b; respectively. Preliminary μCT results showed: G1 no bone defect repair; G2: poor repair; G3: repair; G4: overgrowth of bone tissue around the bone callus and G5: repair without bone overgrowth. Our findings showed that the addition of TPT to SBM mixture accelerated the bone repair process while the daily injection did not produce any additional improvement in the bone regeneration exerted by SBMes_ES
dc.relation.journalTitleREUNIÓN CONJUNTA SAIC SAI&FAIC SAFIS 2022es_ES
dc.type.subtypeResumenes_ES
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